학력

• 1986년 서울대학교 미생물학과, 이학사
• 1988년 서울대학교 미생물학과, 이학석사
• 1991년 ~ 1995년 미국 Brown 대학교 Bio-Med, 이학박사 (분자면역학 전공)

주요 경력

• 1989년 ~ 1990년 한국외국어대 미생물학과 조교
• 1993년 ~ 1995년 Roger Williams Medical Center/Brown University, 연구원
• 1996년 미국 Harvard 의대, Center for Blood Research, Post-doctoral Research Fellow

• 1996년 ~ 1998년 한국미생물학회, 학술위원

• 1996년 9월 ~ 현재 한국외대 생명공학과 조교수, 부교수, 교수

• 1999년 ~ 2010년 미생물학회지 편집위원

• 2000년 한국분자세포생물학회 국제협력위원

• 2003년 미국 MIT 대학교 방문교수
• 2003년 ~ 2007년 이매진(주) R&D board member

• 2006년 ~ 2007년 미생물학회지 편집실무간사

• 2006년 ~ 2007년 한국외국어대학교 행정지원처장(글로벌캠퍼스)

• 2008년 ~ 2013년 한국외국어대학교 국제사회교육원 원장

• 2019년 ~ 2020년 한국외국어대학교 사업지원처장

• 2018년 7월  ~ 현재 사단법인 퇴계학연구원 이사

• 2022년 1월 ~ 현재 알리아드바이오파마(주) 대표이사

연구 분야

• Cytokine 발현조절
• Cytokine 발현조절을 통한 면역억제제개발
• 비천연 아미노산의 단백질 삽입기술 개발

최근 논문

• Kim, K., Park, C., Yeo, H., Kee, Y., Park, J , and Myung, H.. (2000) Implication of exonuclease activity of bacteriophage P2 old protein for lambda exclusion. J. Microbiol. Biotechnol. 10:272-274
• Jin, H.K., Kim, M., Park, C., Park, J ., and Myung, H. (2001) Interaction of the bacteriophage P2 Tin protein and bacteriophage T4 gp32 protein inhibits growth of bacteriophage T4. J. Microbiol. Biotechnol . 11: 724-726
• Park, C., Kee, Y., Park, J ., and Myung, H. (2002) A nonisotopic assay method for hepatitis C virus NS5B polymerase . J. Viol. Methods 101: 211-214.
• Lee, M.-O., Kang, H.-J., Kim, Y., Oum, J.-H., and Park, J . (2002) Rrepression of FasL e-x-p-r-e-s-s-i-o-n by retinoic acid involves a novel mechanism of inhibition of transactivation function of the nuclear factors of activated T-cells. Eur J Biochem . 269(4):1162-70.
• Oum, J.-H., Han, J., Myung, H., Hleb, M., Sharma, S., and Park, J. (2002) Molecular mechanism of NFAT family proteins for differential regulation of the IL-2 and TNF- α promoters. Mol. Cells 13, 77-84.
• Bae, S.-J., Oum, J.-H., Sharma, S., Park, J., and Lee, S.-W. (2002) In vitro selection of specific RNA inhibitors of NFATc. Biochem. Biophy. Res. Comm . 298: 486-492.
• Han, J., Kim, M., Oum, J.-H., Myung, H., Lee, S.-W., Jeong, S., Sharma, S., and Park, J. (2002) RACK-1, a receptor for activated C kinase, interacts with the transcription factor NFAT and represses its transactivation. Mol. Cells 14: 420-424
• Cho, J-S., Lee, Y.J., Shin, K.-S., Jeong, S., Park, J., and Lee, S-W. (2004) In vitro selection of specific RNA aptamers for the NFAT DNA binding domain. Mol. Cells 18: 17-23
• Lee, M. and Park, J. (2006) Regulation of NFAT activation: a potential therapeutic target for immunosuppression. Molecules and Cells 22: 1-76
• Lee M, Park J., (2006), Regulation of NFAT activation: a potential therapeutic target for immunosuppression, Mol Cells, 22(1):1-7
• Lee, D.Y., Chun, J.H., Ha, H.J., Park, J., Kim, B.S., Oh, H.B., and Rhie, G,E. (2009) Poly-gamma-d-glutamic acid and protective antigen conjugate vaccines induce functional antibodies against the protective antigen and capsule of Bacillus anthracis in guinea-pigs and rabbits. FEMS Immunol. Med. Microbiol. 57:165-172
• Cho, M,H,, Ahn, H.J., Ha, H.J., Park, J., Chun, J.H., Kim, B.S., Oh, H.B., Rhie, G.E. (2009) Bacillus anthracis capsule Activates Caspase-1/ICE and Induces Interleukin-1{beta} release from Differentiated THP-1 and Human Monocyte-derived Dendritic cells. Infect. Immun. 2009 Sep 8. [Epub ahead of print]
• 김경태·박미영·박중찬. (2009) 대장균에서 비천연 아미노산의 위치특이적 삽입을 위한 Amber Suppressor tRNA와 Aminoacyl-tRNA Synthetase의 Amber Suppression 활성 측정 시스템 개발.
  미생물학회지 45: 215-221.
• jung, H.J., Shim, J.S., Park,J.,Ha,H.-J.,Kim,J.-H.,Kim,J.-G.,Kim,N.D.,Yoon,J.H.,andKwon,H.J.(2009) Identification and validation of calmodulin as a binding protein of an anti-proliferative small molecule 3,4-dihydroisoquinolinium salt. proteomics-Clinical App.3:423-432
• Kim, K., Park, M.-Y.,and Park,J.(2009) Establishment of an in vivo reporter system for the evaluation of amber suppression activity in E. coli. Kor. J. Microbial. 45: 215-221.
• Cho, M.H,, Ahn, H.J., Ha, H.J., Park,J.,Chun,J.H.,Kim,B.S.,Oh,H.B.,Rhie,G.E.(2010) Bacillus anthracis capsule Activates Caspase-1/ICE an dInduces Interleukin1{beta} release from Differentiated THP-1 and Human Monocyte-derived Dendritic cells. Infect. Immun. 78:387-392
• Jang, J., Jung, K-T., Park, J., Yoo, C-K., and Rhie, G-E. (2011) The Vibrio cholera VarS/VarA two-component system controls the e-x-p-r-e-s-s-i-o-n of virulence proteins through ToxT regulation. Microbiology 157: 1466-1473
• Singh, A., Ha, H-J., Park, J., Kim, J.H., and Lee, W.K. (2011) 3,4-disubstituted oxazolidin-2-ones as constrained ceramide analogs with anticancer activities. Bioorg. Med. Chem. 19:6174-6181
• Jang, J., Cho, M., Lee, H.-R.., Cha, K., Chun, J-H., Hong, K-J., Park, J., and Rhie, G-E. (2013) Monoclonal antibody against the poly-γ-d-glutamic acid capsule of Bacillus anthracis protects mice from enhanced lethal toxin activity due to capsule and anthrax spore challenge. Bioch. Biophy. Acta 1830: 2804-2812
• Yoon, D-H., Ji, M-K., Ha, H-J., Park, J., Kang, P., and Lee, W.K. (2013) Synthesis and Biological Activities of Tyroscherin Analogs. Bull. Korean Chem. Soc. 34:1899-1902
• Edan, D.S., Choi, I., and Park, J. (2014) Establishment of a Selection System for the site-specific incorporation of unnatural amino acids into protein. Kor. J. Microbiol. 50:1-7
• Lee, H.R., Jeon, J.H., Park, O.K., Chun, J.H., Park, J., and Rhie, G.E. (2015) The poly-γ-D-glutamic acid capsule surrogate of the Bacillus anthracis capsule induces nitric oxide production via the platelet activating factor receptor signaling pathway. Mol. Immunol. 68:244-252
• Jeon, J.H., Lee, H.R., Cho, M.H., Park, O.K., Park, J., Rhie, G.E. (2015) The Poly-γ-D-Glutamic Acid Capsule Surrogate of the Bacillus anthracis Capsule Is a Novel Toll-Like Receptor 2 Agonist. Infect. Immun. 83:3847-3856
• Eyob Tekalign, Ju-Eon Oh, and Jungchan Park (2018) Improving amber suppression activity of an orthogonal pair of Saccharomyces cerevisiae tyrosyl-tRNA synthetase and a variant of E. coli initiator tRNA, fMam tRNACUA, for the efficient incorporation of unnatural amino acids. Kor. J. Microbiol. 54:420-427
• Ahn BE, Bae HW, Lee HR, Woo SJ, Park OK, Jeon JH, Park J, Rhie GE. (2019) A therapeutic human antibody against the domain 4 of the Bacillus anthracis protective antigen shows protective efficacy in a mouse model. Biochem Biophys Res Commun. 509:611-616.
• Kim ET, Kwon KM, Lee MK, Park J, Ahn JH. (2019) Sumoylation of a small isoform of NFATc1 is promoted by PIAS proteins and inhibits transactivation activity. Biochem Biophys Res Commun. 513:172-17

특허

• 엔에프에이티씨에 특이적으로 결합하는 알엔에이 (RNA specifically binding to NFATc).
  등록일 2005. 1. 18. 등록번호 10-0468388
• 3,4-디히드로이소퀴놀리늄유도체및이를포함하는약학조성물
  등록번호: 제10-1018330, 등록일: 2011. 2. 22.

저서/번역서

• Brock의 면역학: 23장 분자면역학, 25장 진단미생물학 및 면역학. (2006) 월드사이언스 pp. 761-816.
• Ha, H-J., Lee, W.R., and Park, J. (2008)
  Chapter 7 Synthetic ceramide analogs for anticancer agents: In Glycolipids; New Research. Editor: Daiki Sasaki. Nova Science Publishers
• Brock의미생물학: 23장분자면역학, 25장진단미생물학및면역학. (2006) 월드사이언스pp. 761-816.